Seattle doctors developed a blood test that determines the parental origin of the RB1 mutation in retinoblastoma.

A new research paper was published in Volume 16 of Genes & Cancer on January 20, 2025, entitled, "Analysis of pathogenic variants in retinoblastoma reveals a potential gain of function mutation." ...

RB1 is one gene among a growing list of tumor suppressor genes. According to the American Cancer Society (2005), at least 30 different tumor suppressor genes have been identified, including those ...

Esophageal squamous cell carcinoma (ESCC) is a severe health threat, being a predominant subtype of esophageal cancer and contributing significantly to cancer-related mortality globally.

Molecular characteristics of NEPC include a higher frequency of RB1 or TP53 gene alterations, which may involve concurrent loss of TP53/RB1. Previously, RNAseq-based androgen receptor (AR) signaling ...

In a separate analysis, expression-based gene enrichment analyses then cross-sectional enrichment ... Sequencing analyses found that RB1 loss was associated with poor overall survival (median 14.1 vs ...